Michelin Development will support new and existing local businesses with advice and funding.
The news comes as civic and business leaders from across the region attended an event today to learn more about the £5m programme.
Guests heard successful applicants could receive unsecured, heavily-subsidised loans and free, independent and expert advice to pave the way for growth.
In addition, Michelin Development will target inward investment by providing grants for companies looking to set up in Dundee.
Now high-potential small and medium-sized enterprises in and around Dundee, Arbroath, Carnoustie and Forfar – or businesses considering investing in these areas – are being urged to get in touch.
Mike Cole head of Michelin Development UK told Wave FM about the scheme's previous success: